genetic variation that simply does not account for a substantial component of phenotypic variance. In the current study, the rs671 variant within ALDH2, which is common in East Asian populations and is known to impact risk for AUD (Edenberg, 2007), was strongly associated with all three outcomes within the EAS-specific results (pConsumption 0.013, pMaxDrinks 0.00014, pSymptoms 0.0039). Nonetheless, this did not translate into significant h2SNP estimates within that ancestry group.
