For our empirical application of MTAG, we build on a recent study by the Social Science Genetic Association Consortium (SSGAC) of three traits that have been found to be highly polygenic and strongly genetically related: depressive symptoms (DEP), neuroticism (NEUR), and subjective well-being (SWB). In these analyses, we combine data from the largest previously published studies7–9,11 with new genome-wide analyses from the genetic testing company 23andMe, Inc., and the first release of the UK Biobank (UKB) data. As depicted in Figure 3, there is substantial overlap between the estimation samples for the three traits. For additional details, see Online Methods and Supplementary Note.
