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Chunk #46 — Online Methods — Derivation of relationship between h2 and hγ2

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Leveraging population admixture to characterize the heritability of complex traits.
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Now consider a more complex model in which the effect size of SNPs can fall into one of L classes such that the effect size distribution is a function of the class L. These classes could be, for example, rare and common variants (used in this work). We defined the genetic distance between ancestral populations within each class as FSTL and the phenotypic variance explained by SNPs in this class as h2L. Again substituting into equation (8) we have,