As shown in Figure 2, Class 1 was characterized by near zero probability of all disorders except anxiety and depression, for which probabilities were modest (.16 and .09, respectively). Given this low risk profile, Class 1 was defined as “Unaffected”. In class 2, alcohol abuse and dependence had a high probability (.60), with lower probabilities for marijuana abuse/dependence (.28), nicotine dependence (.17) conduct disorder (.06), and anxiety disorders (.23), and a “0” probability for depression. Thus, Class 2 was defined by its most prominent endorsement as alcohol abuse/dependence (AUD). Class 3 had very high probabilities for anxiety disorders (.64) and major depression (1.0), moderate probability for alcohol abuse/dependence (.48) and lower probabilities for nicotine dependence (.28), cannabis abuse/dependence (.32) and conduct disorder (.16). Class 3 was termed ‘AUD-MDD-ANX’ class. Class 4 had very high probabilities for the substance use disorders: alcohol abuse/dependence (.94), marijuana abuse/dependence (1.0), nicotine dependence (.51) and conduct disorder (.56), but less elevated probability for anxiety and depression (< .5) Class 4 was labeled the SUD-CD class, since poly-substance use disorder and conduct disorder characterized its profile.
