whether differences in PRS existed across involvement levels (e.g., comparison of the OR between no use and use with no problems vs. the OR between no use and use with 1–2 symptoms). To determine whether specific disorder-substance associations were driven by GENSUB, significant analyses were repeated with GENSUB as a covariate. Covariates across all analyses included sex, age quartiles, three ancestrally informative principal components, and study of origin.
