some features of the baclofen-induced current, including the EC50, differed from those in wild-type neurons. Notably, adenosine and 5HT1AR-dependent currents in Girk2 −/− neurons expressing GIRK2a or GIRK2c did not differ in terms of amplitude from wild-type controls, suggesting that adenosine and 5HT1A receptors may couple preferentially to GIRK1-containining channels, while GABABR may be able to couple effectively to GIRK channels irrespective of channel subtype.
