baclofen-induced inhibition of GABA IPSCs was significantly reduced (to 86% of control) in neurons of EtOH-dependent rats. In addition, in CeA neurons from EtOH-dependent rats, baclofen-induced depression was associated with a smaller increase of the PPF ratio of GABA IPSCs compared to that in neurons of naïve rats. These data suggest that the downregulation of the GABAB system associated with EtOH-dependence may explain in part the increased GABAergic tone reported in dependent rats (Roberto et al. 2008).
