Schizophrenia is a highly heterogeneous and complex disorder. The disorder has classically been thought of us as being caused by the interaction of predisposing genes and detrimental environmental factors. However, heritability has been estimated to be as high as 80% with a sibling recurrence risk ratio of 8.6 16. As a result, we primarily focus in this review on the genetic component and briefly discuss modeling environmental factors in a later section.
