As in our study, Covault et al (2008) found that in the extended haplotypes, the AUD risk was conferred by the GABRG1 and not the GABRA2 haplotype components. Analyses of a best-fit genetic model for markers in the two haplotype block regions led Covault et al (2008) to conclude that there may be a separate contribution to risk for AD by GABRG1 and GABRA2 and that their prior findings of a GABRA2 association with alcoholism (Covault et al, 2004) might be partly due to LD with functional genetic variants in GABRG1.
