About one-third of ever drinkers met criteria for DSM-5 AUD, with an average of 3.3 years between starting to drink and meeting criteria for AUD diagnosis. Offspring with a mother with AUD, whether as the only affected parent or with an affected partner, had from 25-28% significantly increased hazards of transitioning from first drink to an AUD diagnosis. (Table 4) Having just a father with AUD did not significantly increase the hazard of transitioning to AUD, although post hoc testing revealed that the estimates across the parental AUD variations were not significantly different. Increased hazards were observed for ever-use of cannabis, internalizing conditions, externalizing disorders and peer substance use, with increases ranging from 36% (peer use) to 152% (ever-use of cannabis). Neither assaultive nor nonassaultive trauma significantly increased the hazards of transitioning from first drink to AUD.
