number of markers tested, the significance of these results did not survive correction for multiple testing. More recently, several other studies provided independent evidence that the CHRNA5, CHRNA3, and CHRNB4 locus is associated with heavy smoking and nicotine dependence [Berrettini et al., [2008]; Bierut et al., [2008]; Thorgeirsson et al., [2008]]. Interestingly, the associations of these genes with other substance abuse/dependence [Grucza et al., [2008]; Wang et al., [2008]] and with lung cancer [Amos et al., [2008]; Hung et al., [2008]; Thorgeirsson et al., [2008]] were also reported.
