Chunk #49 — SUD Prevalence and qEEG Changes — qEEG in Substance Use Disorders — P300 Abnormalities in Cocaine, Methamphetamine, Heroin Addiction, and Alcoholism
Acute and chronic use of cocaine exerts neuropharmacological effects on amplitude and latency of both anterior and posterior P300 ERP components (Biggins et al. 1997; Fein et al. 1996; Herning et al. 1994a; Kouri et al. 1996; Polich 1990). Longer P300 (P3b) latency without abnormalities in amplitude was reported in several studies on cocaine withdrawal (Herning et al. 1994a; Lukas 1993). Noldy and Carlen (1997) demonstrated effects of cocaine withdrawal on the latency of the P300 in an auditory oddball task. In cocaine-dependent patients, P3a amplitude decrements over frontal areas are persistent even after long periods of abstinence (Bauer 1997). The latency of the P3a was delayed and the amplitude was reduced to novel non-targets in cocaine and alcohol-dependent subjects compared to controls (Biggins et al. 1997; Hada et al. 2000) in auditory and visual three-stimuli oddball tasks.
