Sensitivity to thermal stimuli is a complex trait that has been used as a predictor of sensitivity to analgesic drugs. Thermal nociception (hot plate latency) was performed in two laboratories, namely, ORNL and Memphis in this study. Data collected in this study were compared with a previously published study of thermal nociception by Mogil et al. (1997) and Brigman et al. (2009) (GeneNetwork RecordID: 10897). Correlations ranged from 0.274 and 0.799 (Fig. 5b). There is poor correlation among the data collected at the Memphis and ORNL laboratories and can likely be attributed to the two different hot plate temperatures used. The hot plate test was performed at 52°C at Memphis, whereas at ORNL the hot plate temperature was 54°C. Correlations increase when data are compared with previously published studies. Specifically, ORNL hot plate data have a slightly higher correlation to the Mogil study compared with the Memphis hot plate data. This is likely due to the 54°C that was employed in both the ORNL hot plate study and the Mogil study. The range of values obtained at ORNL and Memphis
