In further independent samples (5,662 cases and 154,224 controls), 43 of the 50 genome-wide significant index SNPs showed the same pattern of allelic association, a level that far surpassed chance (P = 1.05 × 10−7). Despite the modest number of cases in these samples, 18 of the 50 index alleles reached nominal significance (P < 0.05), which again is implausible by chance (P = 1.46 × 10−11). None demonstrated evidence for heterogeneity of effect (Methods and Supplementary Table 6).
