We critically evaluated six independent, European-ancestry cohorts (118,635 cases and 319,269 controls). Supplementary Table 2 summarizes the source and inclusion/exclusion criteria for cases and controls for each cohort. These cohorts used a range of methods for assessing MDD or major depression. Most studies included here applied otherwise typical inclusion and exclusion criteria for both cases and controls (e.g., excluding cases with lifetime bipolar disorder or schizophrenia and excluding controls with major depression).
