LDSC revealed significant genetic correlations (FDR q<0.05) with 400 of nearly 1800 traits (Supplementary Table S8). The most significant of these were poor overall-health rating (UKB, rg=0.55, p=9.71×10−57; 4-category scale, from 1-Excellent to 4-Poor) and mood swings (UKB, rg =0.66, p=1.07×10−56). Among the other most interesting statistically significant genetic correlations were with neuroticism (UKB, rg=0.56, p=1.28×−10−44), having seen a doctor (GP) for nerves, anxiety, tension or depression (UKB, rg = 0.58, p=1.54×10−41), years of education (LDHub, r =−0.42, p=9.32×10−32), “loneliness, isolation” (UKB, rg =0.56, p=6.63×10−31), depressive symptoms (LDHub, rg =0.64, p=1.00×10−29), current smoker (UKB, rg =0.43, p=3.49×10−29), intelligence (LDHub, rg=−0.53, p=1.20×10−28), alcohol intake frequency (UKB, rg =0.37, p=2.70×10−22), schizophrenia (LD Hub – PGC, rg=0.25, p=5.17×10−12), insomnia (LDHub, rg=0.38, p=9.49×10−10), risk taking (UKB, rg=0.25, p=2.59×10−9), and hypertension (UKB, rg=0.21, p=3.17×10−09).
