The disconnection hypothesis in schizophrenia (Friston, 1999) is supported by repeated reports of abnormalities of white matter (WM) fibers that connect brain regions (Kubicki & Shenton, 2014; Samartzis, Dima, Fusar‐Poli, & Kyriakopoulos, 2014; Wheeler & Voineskos, 2014). The corpus callosum (CC), the largest commissural fiber bundle in the brain, connects the left and the right hemispheres and serves an essential role of relaying sensory, motor, and cognitive information between the homologous regions (Huang et al., 2005; Ribolsi, Daskalakis, Siracusano, & Koch, 2014). Many studies have investigated abnormalities of the CC in schizophrenia with an aim of studying the disconnection between the two hemispheres (Isobe et al., 2016; Ribolsi et al., 2014).
