Chunk #28 — METHODS — MIXTURE OF REGRESSION MODELS

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A comparison of approaches to account for uncertainty in analysis of imputed genotypes.

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For each assumed model below, we construct likelihood ratio statistics to test for statistical significance. To estimate the parameters (μ, β), we maximize the log-likelihood function using the Nelder-Mead Simplex Method [Nelder and Mead, 1965], implemented in the R package optim.