Gene based analysis identified two genome-wide significant genes for two different phenotypes. OTOP1 was associated with DSM-IV criterion count. This gene is related to maintaining metabolic homeostasis but it is not well-studied. BRINP1 showed association with Drinking despite problems. This gene is mostly expressed in brain regions and has been linked to schizophrenia68,69; cognition disorders55, and Parkinson’s disease70. Further studies are needed to test its role in AD.
