In a few additional genes, we observed nominally significant SNPs that did not meet our multiple test significance criterion. These were in CHRNA4, and CHRNB1. There is borderline nominal significance at a nonsynonymous SNP, rs12914008, in CHRNB4 (p = 0.078); this suggestive signal is distinct from the experiment-wide significant findings at rs16969968 and rs578776. Another SNP in CHRNA5, rs2229961, is a nonsynonymous change according to NCBI build 35.1 and has a borderline p-value of 0.053 but is rarer than the other nonsynonymous SNPs in the cluster, rs16969968 and rs12914008.
