The incorporation of genomics data into population-based studies has led to the emergence of genome-wide association studies and a revolution in the way that scientists think about genetics and the etiology of common, complex diseases (1). Because of the rapid progress in genomic technology, investigators can now analyze hundreds of thousands of genetic polymorphisms (2, 3) against an array of disease phenotypes to identify associations. Genome-wide association studies have the potential to complement research focused on biochemical pathways and/or regulatory cascades and thus inspire new hypotheses (4). Increased understanding of disease etiology and mechanisms will facilitate development of interventions, such as novel prophylactic or therapeutic agents.
