Among the six studies employing a whole-brain analysis approach [143], [146], [148], [150]–[152], two further studies described differences between chronic cannabis users and controls [146], [148]. Matochik et al. (2005) [148] found lower grey matter density in the right parahippocampus and greater grey matter density in the precentral gyrus and right thalamus in cannabis users, while Cousjin et al. (2011) [146] found a larger anterior cerebellum in cannabis users. Matochik et al. (2005) [148] also reported differences in white matter density, such as lower density in the left parietal lobe and higher in parahippocampus, fusiform gyrus, lentiform nucleus and pons.
