the two substances: nicotine is a stimulant whereas alcohol is a depressant. So, for example, if those with Asn alleles are more predisposed to enjoy the action of stimulants, they may be less likely to enjoy the effects of depressants. Nevertheless, in the light of the strong comorbidity between nicotine and alcohol dependence in the general population, these findings are puzzling and future studies will be necessary to resolve this issue.
