2003), the last decade has witnessed an explosion of interest in this area. There has been an exponential increase in the number of cGxE studies published, with researchers from diverse backgrounds routinely incorporating cGxE components into their studies. However, there has been growing skepticism about the replicability of many of these findings (e.g., Risch, Herrell, Lehner, Liang, Eaves, Hoh, Griem, Kovacs, et al., 2009) and increasing concern about the quality of this rapidly expanding literature.
