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Chunk #1 — INTRODUCTION

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Significant modulation of mitochondrial electron transport system by nicotine in various rat brain regions.
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other neurotransmitters such as norepinephrine, serotonin, acetylcholine, glutamate, and GABA (Barik and Wonnacott 2006; MacDermott et al. 1999; Schilstrom et al. 2000; Vizi and Lendvai 1999; Wonnacott 1997). Through its interaction directly or indirectly with these genes, pathways, and neurotransmitter systems, nicotine is involved in the regulation of various physiological processes (Dajas-Bailador and Wonnacott 2004; Dasgupta and Chellappan 2006; Dasgupta et al. 2006; Harkness and Millar 2002; Hwang and Li 2006; Kane et al. 2004; Robinson and Kolb 2004), as well as the morphology and function of different organelles (Cucina et al. 2000; Landais et al. 2005; Roy and Sabherwal 1998; Sallette et al. 2005).