Chunk #8 — Results — Cis- and trans-eQTL mapping

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Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

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For breast cancer we observed that rs3803662 [34] is trans-acting on origin recognition complex subunit 6 (ORC6L). This gene is involved in DNA replication and has been frequently used as part of prognostic profiles for predicting the clinical outcome in breast cancer [35], [36].