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Chunk #44 — Discussion

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The role of parental genotype in the intergenerational transmission of externalizing behavior: Evidence for genetic nurturance.
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is not informative about how socioenvironmental factors may operate differently across the ancestry groups, and it does not provide information on any ethnic-racial differences in externalizing behaviors or parenting. Clearly, concerted efforts to have adequate representation of diversity in genetic research is important, and efforts are underway to increase the diversity of participants in genetic research (Hindorff et al., 2018), such as the All of Us Research Program. There are also various new methods under development (e.g., Liang et al., 2022; Ruan et al., 2022) to account for population allele frequency and LD pattern differences across populations to improve cross-ancestry portability of genetic risk information. While these new methodological approaches are likely to help improve accuracy and generalizability of polygenic scores in diverse populations, prioritizing diversity in genetic research is key in fundamentally addressing the problems and ensuring that all racial/ethnic groups benefit from advances related to genetic findings in an equitable manner (Martin et al., 2019).