Second, not all of the genes appearing in the HuGe Navigator have been associated with alcoholism, alcohol dependence, or other forms of AUD. Specifically, we found that of 83 genes in the HuGe Navigator evaluated as part of this review, 32 had neither a statistically significant nor a nominally significant association with AUD. Thus, based on our experience, approximately 40% of the “alcoholism” genes in the HuGe Navigator are not associated with AUD, leaving the number of genes with a reported connection to AUD in the navigator closer to approximately 450. Finally, genes tested in iMOs, but found to not have connections to alcohol response behaviors, are typically not reported, adding further uncertainty to statistical analysis of the number of genes in Table 4. These intrinsic features of the published data make a formal statistical analysis of the overlap impossible.
