Johnson and colleagues (2006) and Treutlein and colleagues (2009a) have reported GWAS results for alcohol dependence. The former reported clusters of nominally significant SNPs, including some located in genes previously associated with addiction-related traits. Treutlein et al. (2009a) employed a two-stage approach and identified two intergenic markers reaching genome-wide significance, as well as nominally significant SNPs located within genes previously implicated in alcohol dependence. In the current study, we describe the results from the first genome-wide association study of comorbid depressive syndrome and alcohol dependence.
