With repeated use, cocaine leads to neuroadaptations in dopaminergic function (as well as neuroadaptations in other catecholamines and glutamatergic and gabaergic systems) [1]–[4]. These neuroadaptations could interfere with the functional connectivity of brain regions modulated by dopamine and thus contribute to the decreased reward sensitivity, enhanced stress reactivity, and executive cognitive dysfunction reported in cocaine abusers [1], [5]–[9].
