Meta-analysis of rs1344706 in all available schizophrenia datasets provided strong evidence for association to schizophrenia (P=2.54×10−11) with an estimated odds ratio of 1.10 (95% CI; 1.07, 1.14) and no evidence for heterogeneity across studies (Cochran’s Q statistic, P=0.35, 22df). A forest plot of for the individual studies is given in figure 2 with further detail in supplemental table 5. A sensitivity analysis (supplemental table 6) revealed that attaining genome-wide significant evidence for association was not dependent on the inclusion of any one sample, though not unexpectedly, the least significant evidence (P=1.19×10−8) for association was observed when the discovery sample was removed, consistent with the expected inflation in the estimated effect size in that sample, though it is notable that a genome wide significant threshold was surpassed even after removal of this discovery sample.
