Chunk #2 — A Multi-level, Integrative Analysis of Ethanol’s Effects on the Nervous System: Bottom-Up and Top-Down Approaches to Finding Ethanol Targets
The bottom-up approach builds from the identification of an ethanol-sensitive molecule followed by determination of its role in acute and chronic ethanol changes in physiology and behavior. On the other hand, top-down approaches begin with ethanol-related physiological or behavioral changes leading to the study of specific molecular mechanisms and brain circuits contributing to these effects.
