Chunk #17 — RESULTS — MTAG Framework — Estimation of Ω

Source

Multi-trait analysis of genome-wide association summary statistics using MTAG.

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We estimate Ω^ by method of moments using the moment condition E(βjβj′−Ω−∑j)=0, with ∑^j substituted in place of ∑j. This is the step that relies on the homogeneous-Ω assumption: the assumption justifies using all SNPs when estimating Ω^.