The strong links between adolescent mental disorders and parental characteristics indicate the importance of the family context in the development of mental disorders. Our finding of a prominent effect of parental education on mental disorders has been well-documented for both child physical and mental health outcomes.39, 40 Divorce was often associated with mental disorders in youth, particularly anxiety, behavior and substance use disorders. The mechanisms underlying the impact of non-intact homes on mental disorders in youth, including both biologic or genetic vulnerability, and indirect influences on disruptions in the home environment, warrant further study.9, 41, 42 However, the significant interactions observed among several sociodemographic characteristics attest to the complexity of these associations. For example, increased rates of substance use disorders among Hispanic adolescents whose parents were divorced may reflect interactions of individual, familial and broader environmental influences that should be considered simultaneously in modeling the nature of risk and resilience in adolescent mental disorders.43, 44 The lack of strong effects for some sociodemographic characteristics, such as poverty, may also be attributable to the multivariate statistical approach that adjusted for confounded variables.