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Chunk #10 — Discussion

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ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2.
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This study identifies several putative SZ-associated genes that are transcriptionally regulated by ZNF804a overexpression. We show that endogenous and recombinant ZNF804a localize to the nucleus of neural progenitor cells in vitro and in vivo. In addition, we show a direct interaction of endogenous and recombinant protein interacting with regions immediately upstream of the start sites of PRSS16 and COMT, two genes we observed that were upregulated by ZNF804a expression.