Genotype data from probands and controls were analyzed for single-locus and haplotypic associations with the software packages PLINK26 and WHAP.32 Conditional haplotype analyses were carried out as recently described after detection of a significant omnibus association.28 Calculation of intermarker linkage disequilibrium and correction for multiple testing with 100 000 permutations for the 6 individual markers as well as for the 3-locus haplotype was conducted using HaploView, version 4.0.33
