In this German cohort, 2 420 healthy control participants were randomly selected from the general population of Munich, Germany, and contacted by mail. We included 476 individuals (56% females) with GWA data (Illumina HumanHap300 chip) in this study. Several screenings were conducted before the volunteers were enrolled in the study. First, subjects who responded were initially screened by phone for the absence of neuropsychiatric disorders. Second, detailed medical and psychiatric histories were assessed for the participants and their first-degree relatives by using a semi-structured interview56. Third, if no exclusion criteria were fulfilled, they were invited to a comprehensive interview including the SCID to validate the absence of any lifetime psychotic disorder57. Additionally, the Family History Assessment Module was conducted to exclude psychotic disorders among their first-degree relatives. A neurological examination was also conducted to exclude subjects with current central nervous system impairment. If participants were older than 60 years, the Mini Mental Status Test was performed to exclude subjects with possible cognitive impairment58. Only participants with German descent (all 4 grandparents German) were included. Furthermore, a large battery of personality
