Chunk #38 — 3. Neural Substrates for Increased Drug-taking with Extended Access — 3.1. Within-system neuroadaptations

Source: Neurobiological substrates for the dark side of compulsivity in addiction.
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Similar results have been observed in opioid dependence with the opioid partial agonist buprenorphine. Buprenorphine dose-dependently decreased heroin self-administration in opioid-dependent rats (Chen et al., 2006).