CNV. Additionally, rs2815752 near NEGR1 has been previously shown to tag a common deletion [9, 48, 49]. Although the SNP (included in the SNP-GRSS) was nominally associated (p =0.007) with BMI the CNV was not, which could be due in part to the low call rate of this deletion in SAGE (<1%). There were two additional common CNVs nominally associated with class II obesity. The first was a duplication on 1p36.1 (OR = 3.1, p = 0.009, frequency 1.2%) which ranged in length from 49.3 to 150.8 kb with a median value of 66.4 kb. The second was a large deletion on 5q13.2 (OR = 1.5, p = 0.048, frequency 7.7%) and ranged in length from 577.5 to 2238 kb with a median value of 1635 kb. None of the CNV-GRSSs, common or rare, were significantly associated with BMI or obesity in the SAGE sample. Descriptive statistics as well as association results for CNV-GRSSs are presented in Additional file 4: Table S4.
