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Chunk #42 — Materials and Methods — Analysis of global efficiency of whole-brain functional connectivity network

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Network analysis of intrinsic functional brain connectivity in Alzheimer's disease.
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To determine if our characteristic path length findings were robust and reliable, we computed efficiency of functional brain networks. It has been previously reported that efficiency as a graph metric (1) is not susceptible to disconnected nodes, (2) is applicable to unweighted as well as weighted graphs, and (3) is a more meaningful measure of parallel information processing than path length [49]. Efficiency of a graph (Eglobal-net) [50] is inverse of the harmonic mean of the minimum path length between each pair of nodes, Lij, and was computed as,(1)