MiXeR v1.326 was used to estimate each phenotype’s heritability, polygenicity, and discoverability (Supplementary Methods). Briefly, MiXeR uses GWAS summary statistics to model additive genetic effects on a phenotype. Polygenicity is estimated as the number of trait-influencing variants expected to explain 90% of heritability. Discoverability is the average magnitude of additive genetic effects among trait-influencing variants. MiXeR estimates heritability as a function of the product of polygenicity and discoverability.
