cerebral and lobar volumes (including GM and WM sub-compartments) ranged from 0.77 to 0.88; for the caudate, 0.80; and for the corpus callosum, 0.85. The cerebellum has a distinctive heritability profile with an additive genetic effect of only 0.49, although wide confidence intervals merit cautious interpretation. Highly heritable brain morphometric measures provide biologic markers for inherited traits and may serve as targets for genetic linkage and association studies (Gottesman and Gould, 2003).
