To summarize, these validations showed that the expression patterns of the detected BRGs are replicated in independent datasets (UKBEC and GTEx) and indeed showed progressively disturbed patterns in iLBD and PD patients (PD microarray and PD RNA-seq datasets). This was shown for the mean of both BRGs groups (increasing and decreasing), but is also shown for individual BRGs (Supplementary Fig. 6). These findings support the relationship of BRGs with PD vulnerability encountered in brain regions of non-neurological individuals and show how their expression may influence the vulnerability at a region-specific level as well as between patients and controls.
