The meta-analysis included 29 discovery cohorts, with 21 cohorts from Europe, 6 from the Unites States and 2 from Australia. All participants were of European descent. The total sample size was 63,661 for the GWA meta-analysis. The Generation Scotland cohort (N=9,786) was included for replication of GWA top results. For detailed information on each cohort see the eMaterials and methods.