For our discovery GWAS of general risk tolerance (n = 939,908), we performed a sample-size-weighted meta-analysis of results from the UK Biobank (UKB, n = 431,126) and a sample of research participants from 23andMe (n = 508,782). For our replication GWAS of general risk tolerance (n = 35,445), we performed a sample-size-weighted meta-analysis of results from ten smaller cohorts from seven studies: Army STARRS, BASE-II, NFBC 1966, RSIII, STR, UKHLS, and VIKING. The exact measures for the general risk tolerance phenotype vary across cohorts in wording and number of response categories, but all measures are similar and ask about one’s tendency, preparedness, or willingness to take risks in general (Supplementary Table 4).
