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Chunk #31 — Issues related to phenotype harmonization — Genotype imputation

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Phenotype harmonization and cross-study collaboration in GWAS consortia: the GENEVA experience.
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2009; Li et al., 2006], Impute [https://mathgen.stats.ox.ac.uk/impute/impute.html; Marchini et al., 2007; Howie et al., 2009] and BEAGLE [https:faculty.washington.edu/browning/beagle/beagle.html; Browning and Browning, 2009] being the most common). Most WGs are utilizing individual investigators' imputation results and reviewing preliminary analyses of individual study data to ensure that analyses yield similar findings. Another solution for consortia, and one adopted by GENEVA, is to have all genotype data imputed centrally using a standard methodology.