A total of 12,403 incident cases of type 2 diabetes were ascertained and verified (figure 1) during 3.99 million person-years of follow-up of 340,234 EPIC participants (mean follow-up 11.7 years), excluding individuals without stored blood (n=109,625) or without information on reported diabetes status (n=5,821). The total number of incident cases in InterAct further excluded a total of 2,577 verified Danish cases for logistical reasons, as local sample retrieval and DNA extraction of more than the originally anticipated 2,000 cases was not feasible in the required timeframe. A random subcohort of 16,835 individuals was selected; after exclusion of 548 individuals with prevalent diabetes, 129 individuals with unknown and 4 with post-censoring diabetes status, 16,154 individuals were included in the subcohort for InterAct analyses. Due to the random selection, this subcohort also included a random set of 778 individuals who had developed incident diabetes during follow-up.
