multisite IMAGEN consortium have contributed importantly to our understanding of the role of reward circuitry in young people at risk for addiction or early in the process of substance use (e.g., [50], [51], [52]). This study has reported that adolescents who are smokers [50], had prenatal exposure to nicotine [51], or had “potentially problematic” substance use [52] exhibit low VS responsiveness to reward. Similarly, although we were not able to examine brain function before and after onset of alcohol use or dependence, we note that our sample has unique features that allow us to investigate frontostriatal function early in the course of alcohol use problems.
