were corrected for inflation by the method of genomic controls (correction factor=1.42). Nine genetic variants all representing the same association signal on chromosome 8 with P-values less than 1x10−6 were looked up in the deCODE results. The variants in the locus were selected based on LD (0.2 < r2 < 0.7). We included additional markers besides the index SNP in order to be able to evaluate the consistency of direction of association in the replication cohort over a set of variants located in the associated risk locus. The data were meta-analyzed using summary statistics and inverse variance weighted fixed effects model, implemented in the software METAL72. All tested variants demonstrated consistent direction of association in the replication cohort.
