overall expression profiles, we used the COMBAT algorithm58 to account for the effect of batch and linear regression to remove the effects of RIN, post-mortem interval (PMI), sequencing depth, study index (ROS sample or MAP sample), genotyping PCs, age at death, and sex. Finally, only highly expressed genes were kept (mean expression >2 log2-FPKM), resulting in 13,484 expressed genes for eQTL analysis. The details for cis-eQTL analysis are in Ng et al.29.
